General Mechanisms of Action of Oxygen in Infections:
With disease, oxygen delivery is compromised. The inflammatory response following infection is characterized by capillary leak and vasogenic edema that increases the diffusion distance between the vascular supply of dissolved and bound oxygen and adjacent tissues. Tissue edema also leads to variable degrees of tamponade and venous thrombosis, further compromising perfusion and oxygen delivery. Infection leads to microcirculatory shunting (reducing oxygen extraction) and mitochondrial uncoupling.
