Your Cart is Empty
Your Cart is Empty

Rx Pad

Improving the Health of Your Clinical Practice
Font size: +

4 Reasons Why Some Wounds Become Chronic

Various theories have been proposed to explain why some wounds become chronic and nonhealing. Although the complete answer isnot yet available, a great deal has been learned in recent years that sheds light on this phenomenon.

First, there is markedly reduced mitogenic activity (new cell growth). 

Second, inflammation becomes chronic and does not progress. There are elevated levels of TNF-a adn IL-1B. These molecules induce their own synthesis to set up a cycle of non-progressive inflammation, inhibit collagen formation, adn decrease teh production of protease inhibitors. 

Third, chronic wounds have elevated levels of proteases, which destroy growth factors and their receptors, and degrade important matrix proteins such as fibronectin and collagen. The resulting wound bed, lacking attachment sites for migration, is "unfriendly" to keratinocytes, leading to slow or absent wound closure. 

Fourth, fibroblasts in chronic wounds have been shown to be senescent, with decreased capacity to respond to growth factors and decreased capacity for proliferating. This is important because fibroblasts are the cells that produce collagen, fibronectin, and other matrix proteins to form the granulation tissue needed for wound closure.

Accurate wound assessment helps in clinical decision making for management of wounds. 

Textbook of Chronic Wound Care

Source: Shah, Jayesh B, MD; Sheffield, Paul J, PhD; Fife, Caroline E., MD. (2018). Textbook of Chronic Wound Care: An Evidence-Based Approach to Diagnosis and Treatment. North Palm Beach: Best Publishing Company.

Copy of Wound Care Basic Certification Basic Training

Stay Informed

When you subscribe to the blog, we will send you an e-mail when there are new updates on the site so you wouldn't miss them.

Gas Gangrene: Antibiotics vs. HBO2
Video Lesson: The Explosion of Chronic Wounds in t...


No comments made yet. Be the first to submit a comment
Already Registered? Login Here
Monday, 26 September 2022
Wound Care Education Partners
Address: 631 US Highway 1, Suite 307 North Palm Beach, FL 33408
Phone: 561-776-6066
Fax: 561-776-7476

Information: This email address is being protected from spambots. You need JavaScript enabled to view it.
Support: This email address is being protected from spambots. You need JavaScript enabled to view it.
Customer Service Hours: Mon-Fri 10am-4pm ET
Copywrite © Wound Care Education Partners, a company of WCHMedia Group, Inc. | All rights reserved
Find more information at