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Hyperbaric Medicine Practice: The Use of Drugs Under Pressure

Hyperbaric Medicine Practice: The Use of Drugs Under Pressure
New Courses


RN, LPN, CNS, ARNP, CNA, CHT - Category B, CRT, RRT, RCP, CHRN - Category B

Credit Hours: 2.0

License Types Eligible for CEUs: RN, APRN, LN, CNA, CRT, RRT, RCP, CHT - Category B, CHRN - Category B

This 2 - hour online course is based on Hyperbaric Medicine Practice, 4th Edition Chapter 7: The Use of Drugs Under Pressure.


  • A hyperbaric and hyperoxic environment creates numerous considerations for the use of drug therapies within it .
  • First, the physical stress of hyperbaria impacts drug storage and has implications on which containers are most appropriate for use.
  • Second, physiologic changes to the body from hyperbaria and hyperoxia may lead to pharmacokinetic changes in drug disposition.
  • Lastly, hyperbaric oxygen acting as a drug can interact and enhance or ameliorate the physiologic effect of a drug.
  • Most drugs will not interact unfavorably with oxygen, and to study each and every drug in its interaction with hyperbaric oxygen would be not feasible. Unless specific contraindications or precautions have been addressed, it is generally safe to assume a medication can be used. Significant known exceptions and their evidence will be discussed in this course, along with the implications of hyperbaric oxygen use on drug disposition.

* Click on the course title above to view full course details* 


  • The Hyperbaric Oxygen Environment and Oxygen as a Drug
    Practical Considerations
    • Vials
    • Intravenous Infusions
    • InfusionPumps
    • Routes of Administration
  • Pharmacokinetic Considerations
    • Absorption
    • Intramuscular and Subcutaneous Routes
    • Oral Routes
    • Transmucosal Routes
    • Pulmonary Route
    • Distribution
    • Metabolism
    • Elimination
  • Practical Kinetic Application
  • Pharmacodynamic Considerations 
    • Drugs Decreasing Tolerance to Oxygen Toxicity 
      • Agents Increasing or Decreasing Metabolic Rate 
      • Thyroid Replacement
      • Glucocorticoids 
      • Sympathetic Stimulation
      • Central Vasodilators (Mafenide Acetate and Acetazolamide)
    • Drugs Increasing Tolerance to Oxygen Toxicity
      • Vitamin E (AlphaTocopherol)
      • Propranolol
      • Tromethamine (THAM)
      • Chlorpromazine and Promethazine
    • Considerations for Commonly Used Drugs in the Chamber
      • Anticonvulsants
      • Barbiturates
      • Phenytoin
      • Benzodiazepines
      • Opioid Analgesics
      • Analgesics, Non-opioid
    • Drugs Incompatible with Hyperbaric Oxygen
      • Due to Enhanced Drug Toxicity
        • Cisplatin
        • Doxorubicin
    • Drugs Commonly Used with Hyperbaric Oxygen or That May Have Special Consideration
      • Insulin and Antihyperglycemics
      • Sympathomimetics, Vasoactive Compounds, and Antihypertensives
      • Bleomycin Sulfate
      • Disulfiram
      • Ethanol
      • Anesthetics
      • Lidocaine
      • Digitalis/Digoxin
      • Heparin
      • Phenothiazines, Antipsychotics, and Antidepressants
      • Antimicrobials
  • Conclusion

The textbook is not required to participate in this course, materials that you will need are provided. However, the textbook Hyperbaric Medicine Practice, 4th Edition can be puchased from Best Publishing Company and will be a compliment to this course.


WCHMedia Group, Inc. d/b/a Wound Care Education Partners is a professional medical education company composed of specialized educators who are licensed and/or certified in their area of expertise. Wound Care Education Partners is the leading provider of education in the disciplines of wound care, hyperbaric medicine and diving medicine.

Since 2008, Wound Care Education Partners has been providing the highest quality educational programs in the marketplace, including live-educational activities and online programs. Our specialized group of educators is composed of practitioners and researchers who are focused on providing the most up-to-date, scientifically relevant and meaningful healthcare education programs to medical facilities and clinical staff, home healthcare agencies and individuals.

Date of the activity’s original release – April 5, 2024

License types eligible for credits: RN, APRN, LN, CNA, CRT, RRT, RCP. Provided through the Florida State Board of Nursing and the CE is reciprocal for nurses in the United States. Florida nursing credits are reciprocal and approved for nurses within all states. Receiving credit for Florida providers is simple, attend the course and our staff will upload your credits directly to the Florida State database. For out of state credit, we provide all the necessary paperwork for you to file with the respective nursing board.


The information provided at this enduring material activity is for continuing education purposes only. The lecture content, statements or opinions expressed however, do not necessarily represent those of Wound Care Education Partners (WCEP), its affiliates or its employees.

No commercial support was received for this activity.

Hardware/Software Requirements

Hardware required for a learner to participate in this journal-based enduring material activity includes:
Computer with internet connection and a modern, updated browser
Note: If using IE 6, IE 7, or IE 8 we cannot guarantee that the courses will work.
Keyboard to take the quizzes
This textbook-based Internet Enduring Material activity is produced for online use.

Provider Contact Information

If at any time during participation in this online enduring material event, a learner can contact WCEP, by clicking on "Contact Us" tab located on the bottom right hand side of the menu bar found at the bottom of the screen. Also, the contact phone number and email address (hotlink) is always displayed on the bottom center of the screen.

Wound Care Education Partners (WCEP)
631 U.S. Highway 1, Suite 307
North Palm Beach, FL 33408
Phone: +1-561-776-6066
Fax: +1-561-776-7476

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